Denosumab Produces Promising Results Against Giant Cell Tumor of the Bone In a Phase II clinical trial, 86% of patients with giant cell tumor of the bone responded to treatment with the investigational targeted therapy denosumab. These results were presented... Continue Reading
Osteosarcoma Overview (March 18, 2009)Overview Osteosarcoma is the most common type of cancer of the bone. It is the third most common malignancy in children and adolescents, accounting for approximately 5% of all cancers in these age groups. In children and adolescents, 50% of osteosarcomas... Continue Reading
Denosumab Reduces the Risk of Bone Fractures (September 17, 2008)Denosumab Reduces the Risk of Bone Fractures According to the results of a Phase III clinical trial, treatment with denosumab significantly reduces the risk of vertebral and hip fractures among postmenopausal women with osteoporosis. These results were... Continue Reading
Shortened Interval Between Chemotherapy Cycles Does Not Improve Survival with Osteosarcoma (January 23, 2007)Shortened Interval Between Chemotherapy Cycles Does Not Improve Survival with Osteosarcoma According to the results of a study published in the Journal of the National Cancer Institute, osteosarcoma patients treated with the chemotherapy drugs cisplatin... Continue Reading
Heart Dysfunction Continues Long After Treatment with Adriamycin® (July 21, 2006)Heart Dysfunction Continues Long After Treatment with Adriamycin® According to results published in the Annals of Oncology, childhood cancer survivors with bone cancer who were treated with Adriamycin® (doxorubicin) demonstrated declining heart function... Continue Reading
Chemotherapy Combination Produces Promising Results in Ewing’s Sarcoma (April 5, 2006)Chemotherapy Combination Produces Promising Results in Ewing’s Sarcoma Among patients with high-risk Ewing’s sarcoma family of tumors (ESFT), treatment with an intensified chemotherapy regimen of ifosfamide, carboplatin, and etoposide (ICE)... Continue Reading
Computed Tomography (CT) Misses Large Portion of Cancer Spread to Lung in Osteosarcoma (February 7, 2006)Computed Tomography (CT) Misses Large Portion of Cancer Spread to Lung in Osteosarcoma According to a recent article published in the Journal of Pediatric Surgery, computed tomograhy (CT) scans miss over one-third of cancers that have spread to the lung... Continue Reading
Surgical Removal of Cancer Spread to the Lung Significantly Improves Survival in Osteosarcoma (February 7, 2006)Surgical Removal of Cancer Spread to the Lung Significantly Improves Survival in Osteosarcoma According to a recent article published in the Journal of Pediatric Surgery, the surgical removal of cancer spread to the lung significantly improves survival... Continue Reading
Cisplatin Benefits Patients with Metastatic Osteosarcoma (January 12, 2006)Cisplatin Benefits Patients with Metastatic Osteosarcoma A comparison of two clinical trials suggests that the chemotherapy drug cisplatin is more effective against metastatic osteosarcoma than the chemotherapy drug carboplatin. These results were published... Continue Reading
Type of Treatment Influences Survival with Radiation-Induced Osteosarcoma (December 2, 2005)Type of Treatment Influences Survival with Radiation-Induced Osteosarcoma Aggressive treatment appears to significantly improve survival among patients who develop radiation-induced osteosarcoma following treatment of childhood cancer, according to a... Continue Reading